DETERMINATION OF ZONISAMIDE (3-SULPHAMOYLMETHYL-1,2-BENZISOXAZOLE) IN PLASMA AT THERAPEUTIC CONCENTRATIONS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：20

作者：

BERRY, DJ

机构：

[1] Poisons Unit, London, SE14 5ER, Avonley Road

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 534卷

关键词：

D O I：

10.1016/S0378-4347(00)82159-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A selective and sensitive liquid chromatographic method for the determination of zonisamide in small (0.1 ml) plasma samples is described. After adding internal standard, a direct solvent extract of the sample is examined by reversed-phase liquid chromatography with ultra-violet spectrophotometric detection. The method is rapid, simple and capable of determining plasma levels after therapeutic ingestion of zonisamide. Some results from a dose-ranging clinical trial are presented.

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页码：173 / 181

页数：9

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