AMNESIA FOLLOWING DAMAGE TO THE LEFT FORNIX AND TO OTHER SITES - A COMPARATIVE-STUDY

被引:93
作者
GAFFAN, EA
GAFFAN, D
HODGES, JR
机构
[1] UNIV OXFORD,DEPT EXPTL PSYCHOL,OXFORD,ENGLAND
[2] UNIV OXFORD,DEPT CLIN NEUROL,OXFORD,ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1093/brain/114.3.1297
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Two memory-impaired patients, who had suffered damage to the left or both fornix columns during removal of a ventricular cyst, were compared with 3 others having left-sided hippocampal or thalamic lesions, and with normal controls. The tests used were nonverbal-scene recognition, delayed matching-to-sample and concurrent pattern and object discrimination learning. The last two are differentially sensitive to fornix transection and to hippocampal or thalamic ablations in monkeys; however, the patients with fornix damage did not show a distinctive pattern of impariment. The reasons for this discrepancy are discussed. The study adds to the evidence that fornix transection can cause wide-ranging memory disturbances in man.
引用
收藏
页码:1297 / 1313
页数:17
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