EFFECTS OF COCAINE ON TYROSINE-HYDROXYLASE ACTIVITY IN BRAIN-AREAS FROM SHR AND WKY

被引：5

作者：

HOSKINS, B

OH, SK

TSENG, YT

ROCKHOLD, RW

HO, IK

机构：

[1] Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 25卷 / 04期

关键词：

Cocaine; Spontaneously hypertensive rats; Tyrosine hydroxylase in brain; Wistar-Kyoto rats;

D O I：

10.1016/0361-9230(90)90126-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Basal tyrosine hydroxylase activity was the same in the nuclei accumbens and hypothalami of WKY and SHR. Basal striatal enzyme activity was lower in SHR than in WKY. Acute and subacute cocaine administration altered enzyme activity only in striata and nuclei accumbens of WKY. The central dopaminergic system of SHR appears to be less active and less sensitive to cocaine than that of WKY. © 1990.

引用

页码：639 / 641

页数：3

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[2]

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[3]

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