LCMV-SPECIFIC, CLASS-II RESTRICTED CYTOTOXIC T-CELLS IN BETA-2-MICROGLOBULIN DEFICIENT MICE

被引：182

作者：

MULLER, D

KOLLER, BH

WHITTON, JL

LAPAN, KE

BRIGMAN, KK

FRELINGER, JA

机构：

[1] UNIV N CAROLINA, DEPT MICROBIOL & IMMUNOL, CHAPEL HILL, NC 27599 USA

[2] UNIV N CAROLINA, DEPT MED, DIV RHEUMATOL, CHAPEL HILL, NC 27599 USA

[3] UNIV N CAROLINA, DEPT PATHOL, CHAPEL HILL, NC 27599 USA

[4] Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA

[5] UNIV N CAROLINA, LINEBERGER CANC RES CTR, CHAPEL HILL, NC 27599 USA

来源：

SCIENCE | 1992年 / 255卷 / 5051期

关键词：

D O I：

10.1126/science.1347959

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). Beta-2-microglobulin-deficient mice (beta-2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When beta-2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

引用

页码：1576 / 1578

页数：3

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