IN-111 LABELING OF A BRANCHED POLYPEPTIDE DRUG CARRIER WITH A POLY(L-LYSINE) BACKBONE

被引：13

作者：

PIMM, MV ^{[1
]}

CLEGG, JA ^{[1
]}

HUDECZ, F ^{[1
]}

BALDWIN, RW ^{[1
]}

机构：

[1] L EOTVOS UNIV,HUNGARIAN ACAD SCI,PEPTIDE CHEM RES GRP,H-1518 BUDAPEST 112,HUNGARY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 79卷 / 01期

关键词：

POLYMERIC DRUG CARRIER; IN-111; LABELING; BIODISTRIBUTION;

D O I：

10.1016/0378-5173(92)90096-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A synthetic branched polypeptide drug carrier, based on a polylysine backbone with short side chains of three DL-alanine amino acid residues with a terminal glutamic acid residue, has been labelled with In-111 by DTPA chelation. In-111 is a tracer suitable for gamma scintigraphy, thus broadening the techniques available for examining the biodistribution of such polymeric drug carriers.

引用

页码：77 / 80

页数：4

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