Role of iron in the reactivity of mineral fibers

被引:113
作者
Fubini, B
Mollo, L
机构
[1] Università di Torino, Facoltà di Farmacia, Dipartimento di Chimica Inorganica, 10125 Torino
关键词
asbestos fibers; artificial fibers; iron toxicity; free radical release; iron mobilization; chelators; phagocytosis;
D O I
10.1016/0378-4274(95)03531-1
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Any foreign body containing iron may be (or become) highly toxic in vivo. If its solubility in water is poor, surface chemistry governs the reactivity at the solid-liquid interface. Iron toxicity thus increases with the extent of exposed surface. Iron of endogenous origin may also be deposited on the particle surface and be activated under particular circumstances. The chemical processes that implicate surface iron as a primary cause of toxicity are: free radical release, mobilization by chelators, iron-catalyzed reactions. Three kinds of solids are compared: (i) well-known toxic materials, for example asbestos; (ii) non-toxic iron oxides; and (iii) model solids with surface exposed iron prepared for investigations on the reactivity of iron in biological media. The iron content of the solid is not directly related to the biological response: only a small fraction of ions, in a well-defined coordination and redox state, appears involved in the toxicity of the mineral dust.
引用
收藏
页码:951 / 960
页数:10
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