TABLET BOND .2. EXPERIMENTAL CHECK OF MODEL

被引：28

作者：

HIESTAND, EN ^{[1
]}

SMITH, DP ^{[1
]}

机构：

[1] UPJOHN CO,KALAMAZOO,MI 49001

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 67卷 / 03期

关键词：

COMPACT; PARTICLE; TENSILE STRENGTH; HARDNESS; VISCOELASTICITY; SURFACE ENERGY; ELASTIC MODULUS; STRAIN INDEX; RADIUS OF CURVATURE; BRITTLE SEPARATION; DUCTILE EXTENSION;

D O I：

10.1016/0378-5173(91)90206-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The modeling of tablet bond formation requires two mechanisms. The theory was presented in Part I (Hiestand, E.N., Int. J. Pharm., 67 (1991) 217-229). The ductile mechanism if it operates occurs at lower compression forces. The brittle mechanism operates at higher compression forces and may be the only mechanism acting for some materials. Sorbitol is used to illustrate the two mechanism case and phenacetin illustrates the one mechanism case. Cellulose, lactose, and acetaminophen data tend to support the models; but are complicated by particle fracture during compression or mixed regions where both mechanisms may be occurring at different particles within the compact. However, none of the experimental data led to a rejection of these models for tablet bond formation.

引用

页码：231 / 246

页数：16

共 14 条

[1] SURFACE FREE ENERGY - NEW RELATIONSHIP TO BULK ENERGIES [J].