THE NOCICEPTIVE SYSTEMS OF SKIN, PARAVASCULAR TISSUE AND HAND VEINS OF HUMANS AND THEIR SENSITIVITY TO BRADYKININ

被引：21

作者：

KINDGENMILLES, D

KLEMENT, W

ARNDT, JO

机构：

[1] Department of Experimental Anaesthesiology, Heinrich Heine University Düsseldorf, Düsseldorf

来源：

NEUROSCIENCE LETTERS | 1994年 / 181卷 / 1-2期

关键词：

PAIN; PAIN MEASUREMENT; BRADYKININ; NOCICEPTOR; VEIN;

D O I：

10.1016/0304-3940(94)90555-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To study the pain-evoking properties of bradykinn on tbe nociceptive systems of skin, paravascular tissue and hand veins of humans, bradykinin was injected intracutaneously, retrogradially into occluded finger veins for reaching the paravascular tissue or into vascularly isolated hand vein segments of seven subjects. Regardless of the injection site, bradykinin always evoked pain of concentration-related intensity within nearly similar concentration ranges of 0.1-10.0 mu M, yielding congruent pain intensity-concentration relations. Thus, in humans, the nociceptive systems of skin, deep tissue and hand veins are equally sensitive to the endogenous algetic bradykinin.

引用

页码：39 / 42

页数：4

共 16 条

[1] CAPSAICIN DID NOT EVOKE PAIN FROM HUMAN HAND VEIN SEGMENTS BUT DID SO AFTER INJECTIONS INTO THE PARAVASCULAR TISSUE [J].