INTERLEUKIN-3, INTERLEUKIN-6, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND ERYTHROPOIETIN CORD BLOOD-LEVELS OF PRETERM AND TERM NEONATES

被引:17
作者
MEISTER, B
HEROLD, M
MAYR, A
WIDSCHWENDTER, M
MAURER, H
HEIM, K
SPERL, W
机构
[1] UNIV INNSBRUCK, DEPT INTERNAL MED, A-6020 INNSBRUCK, AUSTRIA
[2] UNIV INNSBRUCK, DEPT GYNAECOL & OBSTET, A-6020 INNSBRUCK, AUSTRIA
关键词
FETAL HEMATOPOIESIS; ERYTHROPOIETIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-3; INTERLEUKIN-6;
D O I
10.1007/BF01954082
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The cascade of known haematopoietic growth factors controlling granulomonopoiesis and erythropoiesis includes interleukin-3 (IL-3), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and erythropoietin (EPO). Elevated endogenous IL-3 and IL-6 cord blood levels in infection-free premature and mature neonates may reflect their possible role for expansion of haematopoietic progenitor cells, granulocytes and monocytes. Within the erythroid lineage a synergistic action of IL-3, IL-6 and EPO can be assumed. To identify the regulatory role in fetal haematopoietic expansion cord blood plasma levels of these haematopoietic growth factors were assessed in 19 premature and 20 mature infants using commercial enzyme-linked immunosorbent assay and enzyme-amplified sensitivity immuno assay test kits. Peripheral blood IL-3, GM-CSF and EPO were studied in 5 and 10 premature infants respectively. Compared with cord blood levels we found a decline in EPO levels but no decrease of IL-3 and GM-CSF during the lst month of life. We conclude that postnatal decrease in plasma burst-promoting activity levels in preterm infants is mainly explained by low postnatal EPO levels.
引用
收藏
页码:569 / 573
页数:5
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