HEMOGLOBIN AND FREE-RADICALS - IMPLICATIONS FOR THE DEVELOPMENT OF A SAFE BLOOD SUBSTITUTE

被引：56

作者：

ALAYASH, AI ^{[1
]}

CASHON, RE ^{[1
]}

机构：

[1] UNIV MAINE,DEPT BIOCHEM MICROBIOL & MOLEC BIOL,ORONO,ME 04469

来源：

MOLECULAR MEDICINE TODAY | 1995年 / 1卷 / 03期

关键词：

D O I：

10.1016/S1357-4310(95)80089-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two major concerns in the development of cell-free hemoglobin as a blood substitute (i.e. circulatory retention and oxygen delivery) have been resolved successfully by strategic chemical or genetic modification of the protein. However, the redox reactivity of hemoglobin and its impact on the physiological processes has not been fully understood, nor has it been subject to control by design. This article reviews current research into heme-mediated toxicities that potentially constitute serious impediments to the development of a usable blood substitute.

引用

页码：122 / 127

页数：6

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