LONG CIRCULATING MICROPARTICULATE DRUG CARRIERS

被引：556

作者：

STOLNIK, S ^{[1
]}

ILLUM, L ^{[1
]}

DAVIS, SS ^{[1
]}

机构：

[1] UNIV NOTTINGHAM, DEPT PHARMACEUT SCI, NOTTINGHAM NG7 2RD, ENGLAND

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1995年 / 16卷 / 2-3期

关键词：

PARTICULATE (COLLOID) DRUG DELIVERY SYSTEM; POLOXAMER; POLOXAMINE; POLY(ETHYLENE OXIDE); PEG COPOLYMER; DRUG TARGETING; BIODEGRADABLE MATERIAL; PROTEIN ADSORPTION; BIODISTRIBUTION;

D O I：

10.1016/0169-409X(95)00025-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To exert its activity a drug must reach its pharmacological site(s) of action(s) within the body. One of the current approaches to achieve site specific delivery utilises the use of a carrier. This review focuses on the physicochemical and biological properties of polymeric particulate carriers in the nanometre size range surface modified by poly(ethylene oxide) (PEO). Such systems are able to bypass the normal physiological defence processes occurring after the intravenous injection of particulates and, depending on the particle size and PEO layer properties, remain for a prolonged period of time in the systemic circulation, or have a degree of selectivity for sites of deposition within the body.

引用

页码：195 / 214

页数：20

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