THE INVITRO EFFECTS OF NICOTINE AND COTININE ON PROSTACYCLIN AND THROMBOXANE BIOSYNTHESIS

被引：15

作者：

CHAHINE, R ^{[1
]}

CALDERONE, A ^{[1
]}

NAVARRODELMASURE, C ^{[1
]}

机构：

[1] INST PHYSIOL, F-31400 TOULOUSE, FRANCE

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 40卷 / 04期

关键词：

D O I：

10.1016/0952-3278(90)90047-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The comparative effects of nicotine and cotinine on the biosynthesis of prostacyclin (PGI2) and thromboxane A2 (TXA2) in the horse aorta and platelet microsomes were studied. TXB2 and 6-keto PGF1a stable metabolites of TXA2 and PGI2 respectively were determined by radioimmunoassay. TXA2 production in the presence of either nicotine or cotinine treatment was not altered. However, a dose dependent inhibition of PGI2 biosynthesis, and a dose dependent stimulation of PGI2 biosynthesis, was observed in the presence of nicotine and cotinine respectively. Moreover, cotinine (10b3 M) was able to prevent the inhibitory effect of nicotine on PGI2 synthetase when preincubated with horse aorta microsomes. It appears that cotinine, the major nicotine metabolite resulting from a breakdown process, could be useful for the organism, at least for the cardiovascular system. © 1990.

引用

页码：261 / 266

页数：6

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