THE BILIARY ELIMINATION AND ENTEROHEPATIC CIRCULATION OF IBUPROFEN IN RATS

被引：21

作者：

DIETZEL, K ^{[1
]}

BECK, WS ^{[1
]}

SCHNEIDER, HT ^{[1
]}

GEISSLINGER, G ^{[1
]}

BRUNE, K ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG, DEPT PHARMACOL & TOXICOL, W-8520 ERLANGEN, GERMANY

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 01期

关键词：

biliary elimination; enterohepatic cycling; ibuprofen; nonsteroidal antiinflammatory drugs (NSAID); pharmacokinetics in rats;

D O I：

10.1023/A:1015847912059

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biliary and urinary excretion of ibuprofen and its metabolites were determined in rats after intravenous and peroral administration of 25 and 100 mg/kg of the drug. Within 24 hours 48% of the low i.v. dose and 59% of the high i.v. dose were eliminated via bile as ibuprofen and its metabolites. Following oral administration 40 to 41% of the dose were recovered in bile, whereas 16 to 32% of the dose were eliminated in urine, resulting in an overall drug recovery of 66 to 79% within 24 hours. Upon infusion of bile containing ibuprofen and its metabolites into the duodenum substantial enterohepatic cycling of the drug occurred in the rat. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：87 / 90

页数：4

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