SYNTHESIS OF BIOLOGICALLY-ACTIVE [2.2]PARACYCLOPHANES

被引:9
作者
ALY, AA [1 ]
HASSAN, AA [1 ]
MOURAD, AFE [1 ]
HOPF, H [1 ]
机构
[1] TECH UNIV BRAUNSCHWEIG,INST ORGAN CHEM,W-3300 BRAUNSCHWEIG,GERMANY
关键词
D O I
10.1002/ardp.19923251002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Claisen reaction of 4-acetyl[2.2]paracyclophane (1) with ethyl acetate and diethyl oxalate affords 4-acetoacetyl[2.2]paracyclophane (2) and ethyl(4-oxaloacetyl[2.2]paracyclophane) (6), respectively. Reaction of 2 and 6 with hydrazines and CuCl2 gave the pyrazole derivatives 4 and 8 in addition to the metal complexes 5 and 9. Mannich reaction of 2 with benzylamine and paraformaldehyde yielded the piperidinone derivative 3. The biological activity of all new compounds was tested.
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页码:625 / 628
页数:4
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