EFFECTS OF HEPATITIS-B AND HEPATITIS-C VIRUS-REPLICATION ON THE ACTIONS OF INTERFERON

被引：4

作者：

FOSTER, GR ^{[1
]}

THOMAS, HC ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,DEPT MED,LONDON W2 1PG,ENGLAND

来源：

ANTIVIRAL RESEARCH | 1994年 / 24卷 / 2-3期

关键词：

HEPATITIS B; HEPATITIS C; INTERFERON;

D O I：

10.1016/0166-3542(94)90061-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many patients chronically infected with hepatitis B or C do not respond to interferon therapy. For hepatitis B infections it is now clear that a viral factor down regulates the cells ability to respond to interferon and hence prevents effective therapy in some patients. In chronic hepatitis C infections, interferon therapy leads to the selection of interferon-resistant viral strains, but the mechanism of this resistance is not yet known.

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收藏

页码：131 / 136

页数：6

相关论文

共 15 条

[1] TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].

DAVIS, GL ;

BALART, LA ;

SCHIFF, ER ;

LINDSAY, K ;

BODENHEIMER, HC ;

PERRILLO, RP ;

CAREY, W ;

JACOBSON, IM ;

PAYNE, J ;

DIENSTAG, JL ;

VANTHIEL, DH ;

TAMBURRO, C ;

LEFKOWITCH, J ;

ALBRECHT, J ;

MESCHIEVITZ, C ;

ORTEGO, TJ ;

GIBAS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506

[2] EXPRESSION OF THE TERMINAL PROTEIN REGION OF HEPATITIS-B VIRUS INHIBITS CELLULAR-RESPONSES TO INTERFERON-ALPHA AND INTERFERON-GAMMA AND DOUBLE-STRANDED-RNA [J].

FOSTER, GR ;

ACKRILL, AM ;

GOLDIN, RD ;

KERR, IM ;

THOMAS, HC ;

STARK, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2888-2892

[3] EXPRESSION OF THE TERMINAL PROTEIN OF HEPATITIS-B VIRUS IS ASSOCIATED WITH FAILURE TO RESPOND TO INTERFERON THERAPY [J].

FOSTER, GR ;

GOLDIN, RD ;

HAY, A ;

MCGARVEY, MJ ;

STARK, GR ;

THOMAS, HC .

HEPATOLOGY, 1993, 17 (05) :757-762

[4] HCV INFECTION, HEPATIC HLA DISPLAY AND COMPOSITION OF THE MONONUCLEAR CELL INFLAMMATORY INFILTRATE IN CHRONIC-ALCOHOLIC LIVER-DISEASE [J].

FRENI, MA ;

AJELLO, A ;

RESTA, ML ;

GAETA, GB ;

SPADARO, A ;

FAVA, A ;

CALAPRISTI, I ;

ALESSI, N ;

FERRAU, O .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1991, 21 (06) :586-591

[5] ANTIVIRAL THERAPY - HEPATITIS-B [J].

JACYNA, MR ;

THOMAS, HC .

BRITISH MEDICAL BULLETIN, 1990, 46 (02) :368-382

[6] RANDOMIZED CONTROLLED TRIAL OF INTERFERON-ALPHA (LYMPHOBLASTOID INTERFERON) IN CHRONIC NON-A-HEPATITIS NON-B-HEPATITIS [J].

JACYNA, MR ;

BROOKS, MG ;

LOKE, RHT ;

MAIN, J ;

MURRAYLYON, IM ;

THOMAS, HC .

BRITISH MEDICAL JOURNAL, 1989, 298 (6666) :80-82

[7] 2ND PROTEASOME-RELATED GENE IN THE HUMAN MHC CLASS-II REGION [J].

KELLY, A ;

POWIS, SH ;

GLYNNE, R ;

RADLEY, E ;

BECK, S ;

TROWSDALE, J .

NATURE, 1991, 353 (6345) :667-668

[8] ADENOVIRUS VAI RNA ANTAGONIZES THE ANTIVIRAL ACTION OF INTERFERON BY PREVENTING ACTIVATION OF THE INTERFERON-INDUCED ELF-2-ALPHA KINASE [J].

KITAJEWSKI, J ;

SCHNEIDER, RJ ;

SAFER, B ;

MUNEMITSU, SM ;

SAMUEL, CE ;

THIMMAPPAYA, B ;

SHENK, T .

CELL, 1986, 45 (02) :195-200

[9] HEPATIC HLA-ANTIGEN DISPLAY IN CHRONIC HEPATITIS-B VIRUS-INFECTION - RELATION TO HEPATIC EXPRESSION OF HBV GENOME GENE-PRODUCTS AND LIVER HISTOLOGY [J].

LAU, JYN ;

BIRD, GLA ;

NAOUMOV, NV ;

WILLIAMS, R .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (05) :888-895

[10] THE DEGREE OF VARIABILITY IN THE AMINO TERMINAL REGION OF THE E2/NS1 PROTEIN OF HEPATITIS-C VIRUS CORRELATES WITH RESPONSIVENESS TO INTERFERON THERAPY IN VIREMIC PATIENTS [J].

OKADA, S ;

AKAHANE, Y ;

SUZUKI, H ;

OKAMOTO, H ;

MISHIRO, S .

HEPATOLOGY, 1992, 16 (03) :619-624