THE VALUE OF THE STENTLESS BIOVALVE PROSTHESIS - AN EXPERIMENTAL-STUDY

被引：42

作者：

HAZEKAMP, MG

GOFFIN, YA

HUYSMANS, HA

CICHON, A

机构：

[1] Department of Cardiothoracic Surgery, University Hospital, Leiden

[2] European Homograft Bank, Brussels

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1993年 / 7卷 / 10期

关键词：

STENTLESS BIOVALVE PROSTHESIS; AORTIC VALVE REPLACEMENT; VALVE DEGENERATION; AORTIC ROOT EXPANSION; HOMOGRAFT;

D O I：

10.1016/1010-7940(93)90048-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical use of the stentless bioprosthesis has not yet been accepted world-wide. Experimental studies are scarce. In a study in growing pigs, 23 aortic valve replacements were performed (7 stented bioprostheses (STB), 10 stentless bioprostheses (SLB) and 6 cryopreserved homografts (CAH)). Valves were studied macroscopically and microscopically after explantation. Five animals died between 1.5 and 4 months after implantation. Two STBs showed extreme calcific degeneration. A third STB animal died suddenly: this STB showed only minimal leaflet calcification. One SLB was stenosed with a large fibrin deposit in one cusp, a second SLB showed slight cusp calcification and there were paracommissural tears in one cusp. In all other animals the valves were explanted after 5 to 6.5 months. All STBs showed severe calcific degeneration. Five SLBs showed mild calcific degeneration, while three others were unaltered after 6 months. All CAHs were free of calcific degeneration, three were perfect, two had a tear in a commisure and another was prolapsed with a fibrin nodule in one cusp. Fibroblast proliferation was seen in all CAHs. This study shows that SLBs also suffer from calcific degeneration. The speed and extent of valve degeneration were less than in the STB group. The stentless design is an important contribution which may result in a higher durability of bioprosthetic valves.

引用

页码：514 / 519

页数：6

共 33 条

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