HIPPOCAMPAL KINDLING INCREASES THE EXPRESSION OF GLUTAMATE RECEPTOR-A FLIP AND RECEPTOR-B FLIP MESSENGER-RNA IN DENTATE GRANULE CELLS

被引：71

作者：

KAMPHUIS, W ^{[1
]}

MONYER, H ^{[1
]}

DERIJK, TC ^{[1
]}

DASILVA, FHL ^{[1
]}

机构：

[1] UNIV HEIDELBERG,CTR MOLEC BIOL,MOLEC NEUROENDOCRINOL LAB,W-6900 HEIDELBERG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1992年 / 148卷 / 1-2期

关键词：

KINDLING; EPILEPTOGENESIS; GLUTAMATE RECEPTOR MESSENGER RNA; INSITU HYBRIDIZATION; DENTATE GYRUS;

D O I：

10.1016/0304-3940(92)90802-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The level of the mRNAs encoding the AMPA-selective glutamate receptors-A and -B, alternatively splice variants, Flip and Flop, was studied by in situ hybridization in the brains of rats kindled by Schaffer collateral/commissural-fiber stimulation. In comparison to control animals, the expression level of the Flip variant of both GluR-A and GluR-B mRNAs was bilaterally enhanced in the dentate granule neurons of kindled animals 24 h after last-generalized seizure, whereas no obvious alterations were observed in the GluR-A Flop and GluR-B Flop mRNA variants. In kindled animals, studied 1 month after the last seizure, GluR-A Flip and GluR-B Flip mRNA had returned to control levels. We suggest that these changes may result in an enhanced glutamate receptor sensitivity in the fascia dentata during kindling.

引用

页码：51 / 54

页数：4

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