DETERMINATION OF RESIDUAL SOLVENTS IN A TRANSDERMAL SYSTEM BY MEANS OF HEADSPACE GAS-CHROMATOGRAPHY

被引：5

作者：

GROTE, H ^{[1
]}

LEUGERS, G ^{[1
]}

机构：

[1] SCHWARZ GMBH, MITTELSTR 11-13, D-4019 MONHEIM, FED REP GER

来源：

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE | 1987年 / 327卷 / 08期

关键词：

D O I：

10.1007/BF00511907

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Pharmaceutical products have to be tested for impurities including residual solvents. This is also required in production control. The simplest solution to this problem is headspace gas chromatography. This paper describes the determination of residual volatile hydrocarbons in the transdermal system DEPONIT by only one headspace measurement. Accuracy is ensured by the multiple headspace extract technique.

引用

页码：782 / 785

页数：4

共 12 条

[1]

Bicchi C, 1982, Farmaco Prat, V37, P88

[2]

BOYER JF, 1984, LABO PHARMA PROBL TE, V32, P525

[3]

HACHENBERG H, 1981, GIT CHROMATOGRAPHI S, V42

[4]

HACHENBERG H, 1976, GAS CHROMATOGRAPHIC

[5]

IOFFE DV, 1982, HEADSPACE ANAL RELAT

[6] QUANTITATIVE-ANALYSIS OF RESIDUAL SOLVENTS IN FOOD-PACKAGING PRINTED FILMS BY CAPILLARY GAS-CHROMATOGRAPHY WITH MULTIPLE HEADSPACE EXTRACTION [J].

KOLB, B ;

POSPISIL, P ;

AUER, M .

JOURNAL OF CHROMATOGRAPHY, 1981, 204 (JAN) :371-376

[7] QUANTITATIVE HEADSPACE ANALYSIS OF SOLID SAMPLES - A CLASSIFICATION OF VARIOUS SAMPLE TYPES [J].

KOLB, B ;

POSPISIL, P ;

AUER, M .

CHROMATOGRAPHIA, 1984, 19 :113-122

[8]

MCAULLIF C, 1971, CHEM TECHNOL, P46

[9]

PATT L, 1976, PHARM IND, V38, P902

[10] ISOLATION AND CONCENTRATION TECHNIQUES FOR CAPILLARY COLUMN GAS-CHROMATOGRAPHIC ANALYSIS [J].

POOLE, CF ;

SCHUETTE, SA .

JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1983, 6 (10) :526-549

← 1 2 →