STABILITY OF DILTIAZEM IN DIFFERENT BIOLOGICAL-FLUIDS

被引：11

作者：

MCLEAN, AM

CEFALI, EA

RODEN, JS

GONZALEZ, MA

BIALER, M

机构：

[1] SCHERING PLOUGH RES MIAMI,1500 SW 66TH AVE,PEMBROKE PINES,FL 33023

[2] HEBREW UNIV JERUSALEM,SCH PHARM,JERUSALEM,ISRAEL

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1991年 / 12卷 / 05期

关键词：

DILTIAZEM; STABILITY; AQUEOUS-SOLUTION; PHARMACOKINETICS; METABOLITES; DEGRADATION; KINETICS;

D O I：

10.1002/bdd.2510120502

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The hydrolysis of diltiazem in biological fluids: whole blood, plasma, and gastric fluid was investigated under conditions considered close to the physiological situation. The most significant rate of hydrolytic degradation was found in whole blood (half-life of 27 h), followed by plasma (half-life of 88 h), while the least significant degradation rate was observed in gastric fluid (half-life 153 h). The kinetic profiles of diltiazem hydrolysis indicate that hydrolytic degradation in the biological fluids makes a minimal contribution to the clearance and disposition of the drug.

引用

页码：327 / 334

页数：8

共 18 条

[1]

ANDERSSON KE, 1985, ACTA PHARMACOL TOX, V57, P1

[2]

BIANCHETTI G, 1989, EUR J CLIN PHARMACOL, V36, pA242

[3] STABILITY STUDY OF DILTIAZEM AND 2 OF ITS METABOLITES USING A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD [J].