DNA-ADDUCTS CAUSED BY TAMOXIFEN AND TOREMIFENE IN HUMAN MICROSOMAL SYSTEM AND LYMPHOCYTES IN-VITRO

被引：46

作者：

HEMMINKI, K

WIDLAK, P

HOU, SM

机构：

[1] Center for Nutrition and Toxicology, Karolinska Institute

来源：

CARCINOGENESIS | 1995年 / 16卷 / 07期

关键词：

D O I：

10.1093/carcin/16.7.1661

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA-binding of tamoxifen and toremifene was studied in rat in vivo, in human and rat microsomes in vitro, and in cultured primary human lymphocytes by P-32-postlabelling. Only tamoxifen caused DNA adducts in rat liver. Both compounds induced adducts in both rat and human microsomal systems and in cultured lymphocytes. The levels of adducts in microsomes and lymphocytes were low, ca. 1 adduct/10(9) nucleotides. Toremifene showed lower binding in each system, and in lymhocytes adducts were only detected at a cytotoxic dose level.

引用

页码：1661 / 1664

页数：4

共 20 条

[1]

HAN XL, 1992, CANCER RES, V52, P1360

[2]

HARD GC, 1993, CANCER RES, V53, P4534

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