CHARACTERIZATION OF NATIVE AND RECOMBINANT INTERLEUKIN-1 INHIBITOR ON T-CELL, MONOCYTE, AND B-CELL RESPONSE TO INTERLEUKIN-1

被引：4

作者：

CHANG, DM ^{[1
]}

EATON, RB ^{[1
]}

SCHUR, PH ^{[1
]}

机构：

[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT RHEUMATOL IMMUNOL, BOSTON, MA 02115 USA

来源：

BIOMEDICAL RESEARCH-TOKYO | 1992年 / 13卷 / 02期

关键词：

D O I：

10.2220/biomedres.13.113

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of human monocyte-generated and recombinant interleukin (IL)-1 inhibitor on selected T cell, monocyte and B cell functions were studied. Neither inhibited IL-1-mediated immunoglobulin production by human mononuclear cells nor zymosan-induced IL-1 production by human monocytes. However, the IL-1 inhibitors significantly suppressed IL-1-alpha-induced IL-1 beta secretion and IL-1-beta-induced IL-1 alpha secretion. They also inhibited IL-1-primed IL-2 production. These observations suggest different effects of IL-1 inhibitor on different human cells, and that recombinant IL-1 inhibitor has similar biological properties to the native product.

引用

页码：113 / 124

页数：12

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