CIRCADIAN TIMEKEEPING DURING PREGNANCY - ENDOGENOUS PHASE-RELATIONSHIPS BETWEEN MATERNAL PLASMA HORMONES AND THE MATERNAL BODY-TEMPERATURE RHYTHM IN PREGNANT RHESUS-MONKEYS

被引:26
作者
HONNEBIER, MBOM
JENKINS, SL
NATHANIELSZ, PW
机构
关键词
D O I
10.1210/en.131.5.2051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nine pregnant rhesus monkeys maintained in constant low level lighting (5 Lux) from 56-80 days gestation (dGA) onward were studied to assess the presence or absence of circadian maternal body temperature and maternal plasma hormone variations. Maternal arterial blood samples were taken every 4 h in six monkeys (105-120 dGA) for 48-56 h and every 2 h in three monkeys (108-115 dGA) for 60 h. Maternal intraabdominal temperature was recorded continuously. Cosinor analysis was used to determine circadian rhythmicity. Individual endogenous timekeeping was demonstrated by 1) free-running circadian variations in maternal body temperature in all nine animals, 2) consistent internal acrophase relationships between the maternal body temperature and maternal plasma cortisol rhythm, and 3) idiosyncrasy of the temporal relationship of detectable rhythms to the external environment in individual animals. Only one animal had a significant maternal plasma ACTH rhythm, whereas the presence of 24-h variations in the other hormones varied in individual animals. The mean +/- SD acrophase profiles in hours from the temperature acrophase in those animals who showed significant rhythms were 19.7 +/- 0.6 (n = 8) for cortisol, 19.4 +/- 2.4 (n = 6) for dehydroepiandrosterone sulfate, 8.3 +/- 1.1 (n = 6) for progesterone, and 18.9 +/- 1.6 (n = 3) for estradiol. We conclude that 24-h variations in maternal plasma hormones are truly endogenously generated and not passively dependent on the light-dark cycle. The maternal circadian system regulates the 24 h temporal organization of endogenous plasma hormone variations. We hypothesize that rhythms in cortisol, dehydroepiandrosterone sulfate, progesterone, and estradiol during pregnancy are directly or indirectly governed by the maternal hypothalamus via the circadian oscillatory output of the maternal adrenal.
引用
收藏
页码:2051 / 2058
页数:8
相关论文
共 46 条
  • [1] MODIFICATIONS OF ULTRADIAN AND CIRCADIAN-RHYTHMS OF FETAL HEART-RATE AFTER FETAL-MATERNAL ADRENAL-GLAND SUPPRESSION - A DOUBLE-BLIND-STUDY
    ARDUINI, D
    RIZZO, G
    PARLATI, E
    GIORLANDINO, C
    VALENSISE, H
    DELLACQUA, S
    ROMANNINI, C
    [J]. PRENATAL DIAGNOSIS, 1986, 6 (06) : 409 - 417
  • [2] ASCHOFF J, 1954, PFLUGERS ARCH PHYSL, V260, P51
  • [3] ENDOCRINE CHANGES DURING 48 HOURS OF FOOD WITHDRAWAL IN THE PREGNANT RHESUS-MONKEY IN THE LAST 3RD OF GESTATION
    BINIENDA, Z
    MASSMANN, A
    WIMSATT, J
    HONNEBIER, MBOM
    FIGUEROA, JP
    REIMERS, TJ
    NATHANIELSZ, PW
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (06) : 1184 - 1188
  • [4] BUNNING E, 1964, PHYSL CLOCK ENDOGENO, P56
  • [5] RELATION BETWEEN DIURNAL CHANGES IN PERIPHERAL PLASMA PROGESTERONE, CORTISOL, AND ESTRIOL IN NORMAL WOMEN AT 30-31, 34-35, AND 38-39 WEEKS OF GESTATION
    CHALLIS, JRG
    SPRAGUE, C
    PATRICK, JE
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1983, 16 (01) : 33 - 44
  • [6] MATERNAL AND FETAL PRODUCTION-RATES OF PROGESTERONE IN RHESUS MACAQUES - PLACENTAL-TRANSFER AND CONVERSION TO CORTISOL
    DUCSAY, CA
    STANCZYK, FZ
    NOVY, MJ
    [J]. ENDOCRINOLOGY, 1985, 117 (03) : 1253 - 1258
  • [7] CHARACTERISTICS AND ANALYSIS OF UTERINE ELECTROMYOGRAPHIC ACTIVITY IN THE PREGNANT SHEEP
    FIGUEROA, JP
    MAHAN, S
    POORE, ER
    NATHANIELSZ, PW
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1985, 151 (04) : 524 - 531
  • [8] ALTERATION OF 24-HOUR RHYTHMS IN MYOMETRIAL ACTIVITY IN THE CHRONICALLY CATHETERIZED PREGNANT RHESUS-MONKEY AFTER A 6-HOUR SHIFT IN THE LIGHT-DARK CYCLE
    FIGUEROA, JP
    HONNEBIER, MBOM
    JENKINS, S
    NATHANIELSZ, PW
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (02) : 648 - 654
  • [9] GENAZZANI AR, 1977, ACTA ENDOCRINOL-COP, V83, P800
  • [10] GOWILL RH, 1971, GEN COMP ENDOCR, V16, P21