LOVASTATIN INDUCES GROWTH-INHIBITION AND APOPTOSIS IN HUMAN-MALIGNANT GLIOMA-CELLS

被引：166

作者：

JONES, KD

COULDWELL, WT

HINTON, DR

SU, YH

HE, SK

ANKER, L

LAW, RE

机构：

[1] UNIV SO CALIF,SCH MED,DEPT NEUROL SURG,LOS ANGELES,CA 90033

[2] UNIV SO CALIF,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90033

[3] UNIV SO CALIF,SCH MED,DEPT MED,DIV ENDOCRINOL DIABET & HYPERTENS,LOS ANGELES,CA 90033

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The competitive HMG-CoA reductase inhibitor lovastatin has been shown to suppress growth and induce morphological changes in a variety of non-glioma tumor cell lines. This study assesses the effects of this agent on the growth and survival of the human malignant glioma cell lines A172 and U87-MG. The response to the drug was investigated using a cell proliferation assay which revealed significant dose-dependent growth inhibition. Treatment with as little as 100 nM lovastatin over a period of 72 hours led to DNA degradation into nucleosome-sized fragments characteristic of apoptosis. Our data suggest that HMG-CoA reductase inhibitors such as lovastatin merit further investigation as potential therapeutic agents for the treatment of malignant gliomas. (C) 1994 Academic Press, Inc.

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页码：1681 / 1687

页数：7

相关论文

共 27 条

[1] COMPARISON OF DEXAMETHASONE AND LOVASTATIN (MEVINOLIN) AS GROWTH-INHIBITORS IN CULTURES OF T-CELL DERIVED HUMAN ACUTE-LEUKEMIA LINES (CEM) [J].

BANSAL, N ;

HOULE, AG ;

MELNYKOVYCH, G .

LEUKEMIA RESEARCH, 1989, 13 (10) :875-882

[2] HETEROGENEITY OF GENOTYPIC AND PHENOTYPIC CHARACTERISTICS OF 15 PERMANENT CELL-LINES DERIVED FROM HUMAN GLIOMAS [J].

BIGNER, DD ;

BIGNER, SH ;

PONTEN, J ;

WESTERMARK, B ;

MAHALEY, MS ;

RUOSLAHTI, E ;

HERSCHMAN, H ;

ENG, LF ;

WIKSTRAND, CJ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1981, 40 (03) :201-229

[3] CONCENTRATIONS OF PRAVASTATIN AND LOVASTATIN IN CEREBROSPINAL-FLUID IN HEALTHY-SUBJECTS [J].

BOTTI, RE ;

TRISCARI, J ;

PAN, HY ;

ZAYAT, J .

CLINICAL NEUROPHARMACOLOGY, 1991, 14 (03) :256-261

[4] PROTEIN-KINASE-C INHIBITORS INDUCE APOPTOSIS IN HUMAN-MALIGNANT GLIOMA CELL-LINES [J].

COULDWELL, WT ;

HINTON, DR ;

HE, SK ;

CHEN, TC ;

SEBAT, I ;

WEISS, MH ;

LAW, RE .

FEBS LETTERS, 1994, 345 (01) :43-46

[5] CLINICAL AND RADIOGRAPHIC RESPONSE IN A MINORITY OF PATIENTS WITH RECURRENT MALIGNANT GLIOMAS TREATED WITH HIGH-DOSE TAMOXIFEN [J].

COULDWELL, WT ;

WEISS, MH ;

DEGIORGIO, CM ;

WEINER, LP ;

HINTON, DR ;

EHRESMANN, GR ;

CONTI, PS ;

APUZZO, MLJ ;

KORNBLITH, P ;

DETRIBOLET, N ;

TAOA, M ;

LEVIN, VA ;

OLDFIELD, EH .

NEUROSURGERY, 1993, 32 (03) :485-490

[6] HYPERICIN - A POTENTIAL ANTIGLIOMA THERAPY [J].

COULDWELL, WT ;

GOPALAKRISHNA, R ;

HINTON, DR ;

HE, SK ;

WEISS, MH ;

LAW, RE ;

APUZZO, MLJ .

NEUROSURGERY, 1994, 35 (04) :705-709

[7] COMMON MODIFICATIONS OF TRIMERIC-G PROTEINS AND RAS PROTEIN - INVOLVEMENT OF POLYISOPRENYLATION [J].

FINEGOLD, AA ;

SCHAFER, WR ;

RINE, J ;

WHITEWAY, M ;

TAMANOI, F .

SCIENCE, 1990, 249 (4965) :165-169

[8] LOVASTATIN AND OTHER HMG-COA REDUCTASE INHIBITORS [J].

FRISHMAN, WH ;

ZIMETBAUM, P ;

NADELMANN, J .

JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 29 (11) :975-982

[9] APOPTOSIS - A DIFFERENT TYPE OF CELL-DEATH [J].

GERSCHENSON, LE ;

ROTELLO, RJ .

FASEB JOURNAL, 1992, 6 (07) :2450-2455

[10] ALL RAS PROTEINS ARE POLYISOPRENYLATED BUT ONLY SOME ARE PALMITOYLATED [J].

HANCOCK, JF ;

MAGEE, AI ;

CHILDS, JE ;

MARSHALL, CJ .

CELL, 1989, 57 (07) :1167-1177