PTILOMYCALIN-A, CRAMBESCIDIN-800 AND RELATED NEW HIGHLY CYTOTOXIC GUANIDINE ALKALOIDS FROM THE STARFISHES FROMIA-MONILIS AND CELERINA-HEFFERNANI

被引：80

作者：

PALAGIANO, E

DEMARINO, S

MINALE, L

RICCIO, R

ZOLLO, F

IORIZZI, M

CARRE, JB

DEBITUS, C

LUCARAIN, L

PROVOST, J

机构：

[1] UNIV NAPLES FEDERICO II, DIPARTIMENTO CHIM SOSTANZE NAT, I-80131 NAPLES, ITALY

[2] UNIV MOLISE, I-86100 CAMPOBASSO, ITALY

[3] ORSTOM, NOUMEA, NEW CALEDONIA

[4] RHONE POULENC RORER, CTR RECH VITRY ALFORTVILLE, F-94403 VITRY, FRANCE

来源：

TETRAHEDRON | 1995年 / 51卷 / 12期

关键词：

D O I：

10.1016/0040-4020(95)00082-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel pentacyclic guanidine alkaloids, celeromycalin 3 and fromiamycalin 4, have been isolated from the New Caledonian starfishes Celerina heffernani and Fromia monilis, respectively. Also found in Celerina heffernani are the known ptilomycalin A (1) and crambescidin 800 (2), which latter has been also isolated from Fromia monilis. The new compounds exhibited an high cytotoxic activity like the previous crambescidins. These complex pentacyclic guanidines are typical sponges metabolites and their occurence in starfishes is noteworthy. Fromia monilis also contained the less active component 5, made up from an hydroxyspermidine residue linked to a long chain omega-hydroxyacid.

引用

页码：3675 / 3682

页数：8

共 14 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].