THE ROLE OF SPECIFIC IgG AND COMPLEMENT IN COMBATING A PRIMARY MUCOSAL INFECTION OF THE GUT EPITHELIUM

被引：20

作者：

Belzer, C. ^{[1
]}

Liu, Q. ^{[1
]}

Carroll, M. C. ^{[2
]}

Bry, L. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Immune Dis Inst Harvard Med Sch, Dept Pediat Pathol, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY | 2011年 / 1卷 / 04期

关键词：

C; rodentium; complement; mucosal infection;

D O I：

10.1556/EuJMI.1.2011.4.7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of complement and complement-fixing IgG isotypes at mucosal surfaces is ill defined. Previous data have demonstrated that survival of an infection with the attaching and effacing pathogen Citrobacter rodentium requires production of systemic and CD4(+) T cell-dependent IgG. We have found that both complement and complement-fixing IgG isotypes are needed to survive a C. rodentium infection. Our results indicate that both IgG and complement C3b enter the gut lumen and bind epithelially adherent, and fecally shed C. rodentium. Furthermore, C3-deficient mice demonstrate a profound survival defect, though means to replenish C3 in systemic or mucosal sites restores the protective capacity of complement in the host. Our data provide evidence that both IgG and complement interact constructively on both sides of the epithelium to fight colonizing mucosal infections.

引用

页码：311 / 318

页数：8

共 42 条

[1]

Andoh A, 1998, CLIN EXP IMMUNOL, V111, P477

[2] Differential expression of complement proteins and regulatory decay accelerating factor in relation to differentiation of cultured human colon adenocarcinoma cell lines [J].