COLORIMETRIC DETERMINATION OF 7 NONSTEROIDAL ANTIINFLAMMATORY DRUGS USING 2-NITROPHENYLHYDRAZINE HYDROCHLORIDE

被引：40

作者：

ABDELHAY, MH ^{[1
]}

KORANY, MA ^{[1
]}

BEDAIR, MM ^{[1
]}

GAZY, AA ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,FAC PHARM,ALEXANDRIA,EGYPT

来源：

ANALYTICAL LETTERS | 1990年 / 23卷 / 02期

关键词：

2-nitrophenylhydrazine hydrochloride; colorimetry; Nonsteroidal anti-inflammatory drugs determination; pharmaceutical formulations;

D O I：

10.1080/00032719008052444

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, sensitive and convenient calorimetric method for the determination of seven nonsteroidal anti-inflammatory drugs, namely, flufenamic acid, mefenamic acid, niflumic acid, ketoprofen, ibuprofen, diclofenac sodium and indomethacin, was developed. The method is based on reaction of the above mentioned compounds - being carboxilic compounds, reacting with 2-nitrophenyl-hydrazlne in presence of diclohexylcarbodiimide in ethanolic medium to give acid hydrazine, which showed intense violet colour with a maximum absorption at around 550 nm. The effect of reagent concentration (2-nitrophenylhydrazine hydrochloride, pyridine and dicyclohexylcarbodiimide), heating temperature and heating time were studied to optimize reaction conditions. The method was successfully applied to the determination of those drugs in pure and dosage forms, with a relative standard deviation less than 2z. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：281 / 294

页数：14

共 35 条

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[2]

BLAZSEK A, 1985, FARMACIA, V33, P75

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