OCCURRENCE OF HYDRIN-2 (VASOTOCINYL-GLY), A NEW HYDROOSMOTIC NEUROHYPOPHYSEAL PEPTIDE, IN SECRETORY GRANULES ISOLATED FROM THE FROG (RANA-ESCULENTA) NEUROINTERMEDIATE PITUITARY

被引：19

作者：

CHAUVET, J ^{[1
]}

ROUILLE, Y ^{[1
]}

CHAUVET, MT ^{[1
]}

ACHER, R ^{[1
]}

机构：

[1] UNIV PARIS 06,BIOL CHEM LAB,96 BLVD RASPAIL,F-75006 PARIS,FRANCE

来源：

NEUROENDOCRINOLOGY | 1990年 / 51卷 / 02期

关键词：

Frog neurointermediate pituitary; Hydrin; Neurosecretory granules; Vasotocin;

D O I：

10.1159/000125343

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neurohypophyseal secretory granules have ben purified from the frog (Rana esculenta) neurointermediate pituitary gland by sucrose gradient centrifugation, and their polypeptide content has been analyzed by reverse-phase high-pressure liquid chromatography. Aside from vasotocin, mesotocin, and their associated neurophysins, hydrin 2 (vasotocinyl-Gly), previously identified in hydrochloric acid extracts, has been recognized. This finding supports the previous suggestion that hydrin 2, a peptide active on the water permeability of frog bladder and frog skin, is a secreted hormone involved in osmoregulation specific to amphibians. Hydrin 2 has not been found in neurosecretory granules of birds such as the goose. © 1990 S. Karger AG, Basel.

引用

页码：233 / 236

页数：4

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