LONG-TERM PERSISTENT INFECTION OF SWINE MONOCYTES/MACROPHAGES WITH AFRICAN SWINE FEVER VIRUS

被引：44

作者：

CARRILLO, C ^{[1
]}

BORCA, MV ^{[1
]}

AFONSO, CL ^{[1
]}

ONISK, DV ^{[1
]}

ROCK, DL ^{[1
]}

机构：

[1] US AGR RES SERV,PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 01期

关键词：

D O I：

10.1128/JVI.68.1.580-583.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Long-term persistent infection was established in 100% of pigs (n = 19) experimentally infected with African swine fever virus (ASFV). Viral DNA was detected in peripheral blood mononuclear leukocytes (PBML) at greater than 500 days postinfection by a PCR assay. Infectious virus was not, however, isolated from the same PBML samples. In cell fractionation studies of PBML, monocytes/macrophages were found to harbor viral DNA during the persistent phase of infection. This result indicates that monocytes/macrophages are persistently infected with ASFV and that ASFV-swine monocyte/macrophage interactions can result in either lytic or persistent infection.

引用

页码：580 / 583

页数：4

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