SEROTONIN AND ALCOHOL INTAKE, ABUSE, AND DEPENDENCE - CLINICAL-EVIDENCE

被引：284

作者：

LEMARQUAND, D

PIHL, RO

BENKELFAT, C

机构：

[1] MCGILL UNIV, DEPT PSYCHOL, MONTREAL H3A 1B1, PQ, CANADA

[2] MCGILL UNIV, DEPT PSYCHIAT, MONTREAL, PQ, CANADA

来源：

BIOLOGICAL PSYCHIATRY | 1994年 / 36卷 / 05期

关键词：

5-HYDROXYTRYPTAMINE; 5-HT; ALCOHOL; ALCOHOLISM; ALCOHOL DEPENDENCE; HUMANS;

D O I：

10.1016/0006-3223(94)90630-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A large body of literature has emerged concerning the role of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) in the regulation of alcohol intake and the development of alcoholism Despite the wealth of information, the functional significance of this neurotransmitter remains to be fully elucidated. This paper, part one of a two-part review, summarizes the available clinical research along two lines: the effects of alcohol on serotonergic functioning and the effects of pharmacological manipulation of serotonergic functioning on alcohol intake in normal (nonalcohol dependent) and alcohol-dependent individuals. It is concluded that considerable evidence exists to support the notion that some alcoholic individuals may have lowered central serotonin neurotransmission.

引用

页码：326 / 337

页数：12

共 146 条

[1] ELIMINATION OF CENTRALLY FORMED 5-HYDROXYINDOLEACETIC ACID BY CEREBROSPINAL-FLUID AND URINE [J].