THE SHORT-TERM EFFECT OF NICOTINE CHEWING GUM IN PATIENTS WITH PARKINSONS-DISEASE

被引：67

作者：

CLEMENS, P ^{[1
]}

BARON, JA ^{[1
]}

COFFEY, D ^{[1
]}

REEVES, A ^{[1
]}

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DEPT MED,HANOVER,NH 03756

来源：

PSYCHOPHARMACOLOGY | 1995年 / 117卷 / 02期

关键词：

PARKINSONS DISEASE; NICOTINE;

D O I：

10.1007/BF02245195

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Because of the inverse association of cigarette smoking with the risk of Parkinson's disease, we performed a short-term, double-blind, randomized controlled trial of nicotine polacrilex resin gum in patients with this disease. Forty-eight subjects were randomly assigned to chew either nicotine gum or placebo gum three times at 2-h intervals, with evaluation of symptoms before and after the trial. The nicotine gum was reasonably well tolerated, but there were no substantial differences in Parkinson's disease symptoms between the two treatment groups.

引用

页码：253 / 256

页数：4

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