IDENTIFICATION OF AMINO-ACID POLYMORPHISM WITHIN THE LEUCINE-ZIPPER MOTIF OF MOUSE TRANSCRIPTION FACTOR A1

被引：5

作者：

KAJIMOTO, Y

KAWAMORI, R

UMAYAHARA, Y

WATADA, H

IWAMA, N

MORISHIMA, T

YAMASAKI, Y

KAMADA, T

机构：

[1] First Department of Medicine, Osaka University School of Medicine, Suita

来源：

GENE | 1994年 / 139卷 / 02期

关键词：

HELIX-LOOP-HELIX PROTEIN; RECOMBINANT DNA; E47; E2A GENE;

D O I：

10.1016/0378-1119(94)90764-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mouse transcription factor A1 (A1) is a mouse homologue of human E47, a ubiquitously expressed DNA-binding protein which contains a basic region, helix-loop-helix (HLH) and leucine zipper (LZ) motifs [Walker et al., Nucleic Acids Res. 18 (1990) 1159-1166]. Analyses of the nucleotide (nt) sequences of A1 cDNAs isolated from various mouse strains revealed amino acid (aa) polymorphism in the highly conserved region within the LZ motif. Interestingly, the location and pattern of aa deletions are identical to those previously described for the aa polymorphism within the human counterpart, E47 (E12) [Kamps et al., Cell 60 (1990) 547-555].

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页码：247 / 249

页数：3

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