RED-CELL MEMBRANE SODIUM-TRANSPORT - POSSIBLE GENETIC ROLE AND USE IN IDENTIFYING PATIENTS AT RISK OF ESSENTIAL-HYPERTENSION

被引:8
作者
DEAL, JE
SHAH, V
GOODENOUGH, G
DILLON, MJ
机构
[1] Dept. of Paediatric Nephrology, Institute of Child Health, London WC1N 1EH
关键词
D O I
10.1136/adc.65.10.1154
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To investigate the influence of a family history of essential hypertension on abnormalities of red cell membrane sodium transport, 28 hypertensive children and their families were studied. In 15 families one or both parents had either essential hypertension or a strong family history. In 13 families neither parent had essential hypertension or a positive family history. There were significant differences between the children with a positive family history of essential hypertension compared with those without. Values are expressed as mean (SD): intracellular sodium concentration (mmol/l cells) 8.19 (2.18) compared with 6.41 (0.89); sodium efflux rate constant 0.4873 (0.1379) compared with 0.5831 (0.1104); and numbers of sodium-potassium ATPase pump sites (BMax) (nmol/l cells) 7.96 (1.71) compared with 9.56 (1.7). Significant differences were also found when the index hypertensive children were excluded and the normotensive siblings with and without hypertensive family histories were compared. These data suggest that abnormal red cell membrane sodium transport has a familial component, and although it is not caused by the hypertension it may be the earliest pathophysiological step in its development, perhaps allowing the identification of children at risk of essential hypertension.
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页码:1154 / 1157
页数:4
相关论文
共 24 条
[1]  
AALKJAER C, 1986, LANCET, V1, P649
[2]   INCREASED INTRA-LYMPHOCYTIC SODIUM CONTENT IN ESSENTIAL-HYPERTENSION - AN INDEX OF IMPAIRED NA+ CELLULAR-METABOLISM [J].
AMBROSIONI, E ;
COSTA, FV ;
MONTEBUGNOLI, L ;
TARTAGNI, F ;
MAGNANI, B .
CLINICAL SCIENCE, 1981, 61 (02) :181-186
[3]   FAMILIAL AGGREGATION OF BLOOD-PRESSURE AND WEIGHT IN ADOPTIVE FAMILIES .2. ESTIMATION OF THE RELATIVE CONTRIBUTIONS OF GENETIC AND COMMON ENVIRONMENTAL-FACTORS TO BLOOD-PRESSURE CORRELATIONS BETWEEN FAMILY MEMBERS [J].
ANNEST, JL ;
SING, CF ;
BIRON, P ;
MONGEAU, JG .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1979, 110 (04) :492-503
[4]   SODIUM IONS, CALCIUM-IONS, BLOOD-PRESSURE REGULATION, AND HYPERTENSION - REASSESSMENT AND A HYPOTHESIS [J].
BLAUSTEIN, MP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1977, 232 (05) :C165-C173
[5]   INCREASED ERYTHROCYTE LITHIUM-SODIUM COUNTERTRANSPORT IN ESSENTIAL-HYPERTENSION - ITS RELATIONSHIP TO FAMILY HISTORY OF HYPERTENSION [J].
CANALI, M ;
BORGHI, L ;
SANI, E ;
CURTI, A ;
MONTANARI, A ;
NOVARINI, A ;
BORGHETTI, A .
CLINICAL SCIENCE, 1981, 61 :S13-S15
[6]   INCREASED SODIUM-LITHIUM COUNTERTRANSPORT IN RED-CELLS OF PATIENTS WITH ESSENTIAL-HYPERTENSION [J].
CANESSA, M ;
ADRAGNA, N ;
SOLOMON, HS ;
CONNOLLY, TM ;
TOSTESON, DC .
NEW ENGLAND JOURNAL OF MEDICINE, 1980, 302 (14) :772-776
[7]  
Cooper R, 1983, J Hypertens, V1, P145, DOI 10.1097/00004872-198308000-00006
[8]   PLASMA-RENIN ACTIVITY AND ALDOSTERONE CONCENTRATION IN CHILDREN [J].
DILLON, MJ ;
RYNESS, JM .
BMJ-BRITISH MEDICAL JOURNAL, 1975, 4 (5992) :316-319
[9]  
EDMONDSON RPS, 1975, LANCET, V1, P1003
[10]   LABORATORY DISTINCTION BETWEEN ESSENTIAL AND SECONDARY HYPERTENSION BY MEASUREMENT OF ERYTHROCYTE CATION FLUXES [J].
GARAY, RP ;
ELGHOZI, JL ;
DAGHER, G ;
MEYER, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1980, 302 (14) :769-771