CLONING AND CHARACTERIZATION OF THE GENE ENCODING THE ADP-RIBOSYLATION FACTOR IN CANDIDA-ALBICANS

被引：19

作者：

DENICH, KT ^{[1
]}

MALLOY, PJ ^{[1
]}

FELDMAN, D ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DIV ENDOCRINOL,S005,STANFORD,CA 94305

来源：

GENE | 1992年 / 110卷 / 01期

关键词：

GTP-BINDING PROTEINS; SACCHAROMYCES-CEREVISIAE; HUMAN; SEQUENCE HOMOLOGY; FUNGI;

D O I：

10.1016/0378-1119(92)90455-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have cloned and sequenced the gene (ARF) encoding the ADP-ribosylation factor (ARF) of Candida albicans. The gene contains an open reading frame of 537 nucleotides (nt) that codes for a protein with an M(r) of 20259. The C. albicans ARF gene is 67-70% identical at the nt level to other ARF sequences including those of humans; the deduced amino acid sequence of C. albicans ARF shows a 78-83% identity and 89-92% similarity to the other ARFs. Southern analysis of C. albicans genomic DNA suggested the presence of a second ARF gene. The presence of multiple ARF genes is a consistent finding among the other organisms previously shown to have ARFs.

引用

页码：123 / 128

页数：6

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