PREPARATION AND INVIVO EFFECT OF MICROENCAPSULATED CHOLINOTOXIN

被引：2

作者：

MAYSINGER, D

ZORC, B

BUTULA, I

JALSENJAK, I

机构：

[1] UNIV ZAGREB, FAC PHARM & BIOCHEM, A KOVACICA 1, YU-41000 Zagreb, YUGOSLAVIA

[2] MCGILL UNIV, DEPT PHARMACOL & THERAPEUT, MONTREAL H3A 2T5, QUEBEC, CANADA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 63卷 / 02期

关键词：

Choline acetyltransf erase; Cholinotoxin; Enzyme activity; Poly(lactic acid) microcapsules;

D O I：

10.1016/0378-5173(90)90165-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long-term controlled release of a neurotoxin was achieved in vivo by microencapsulating the cholinotoxin in a poly(lactic acid) matrix. A dose of 0.59 nmol of the toxin (in 20 mg of microcapsules) produced a significant reduction in choline acetyltransferase (ChAT) activity in the cortex without affecting other brain structures. © 1990.

引用

页码：149 / 153

页数：5

共 18 条

[1] EFFECT OF SINGLE AND REPEATED CONVULSIONS ON GLUTAMATE-DECARBOXYLASE (GAD) ACTIVITY AND [H-3]MUSCIMOL BINDING IN THE RAT-BRAIN [J].