POTENTIAL ANTIMALARIALS .6. MANNICH-BASES DERIVED FROM 4-[7'-BROMO(AND CHLORO)-1',5'-NAPHTHYRIDIN-4'-YLAMINO]PHENOLS AND 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOL

被引：10

作者：

BARLIN, GB ^{[1
]}

TAN, WL ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, JOHN CURTIN SCH MED RES, MED CHEM GRP, CANBERRA, ACT 2601, AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1986年 / 39卷 / 01期

关键词：

D O I：

10.1071/CH9860051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eleven di-Mannich bases derived from 4-[7''-bromo(and chloro)-1'',5''-naphthyridin-4''-ylamino]phenols and 4-(7''-trifluoromethylquinolin-4''-ylamino)phenol have been prepared. Each of these compounds showed very good antimalarial activity when injected intraperitoneally in a single dose of 50-100 mg/kg to mice infected with Plasmodium vinckei vinckei.

引用

页码：51 / 57

页数：7

共 5 条

[1] POTENTIAL ANTIMALARIALS .2. N4-SUBSTITUTED 2-METHOXY(AND 2-HYDROXY)-1,5-NAPHTHYRIDIN-4-AMINES [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1984, 37 (12) :2469-2477

[2] POTENTIAL ANTIMALARIALS .3. N-4-SUBSTITUTED 7-BROMO-1,5-NAPHTHYRIDIN-4-AMINES [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1985, 38 (03) :459-465

[3] POTENTIAL ANTIMALARIALS .5. 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOLS, 4-[2',7' AND 2',8'-BIS(TRIFLUOROMETHYL)QUINOLIN-4'-YLAMINO]PHENOLS AND N-4-SUBSTITUTED 2,7-(AND 2,8-)BIS(TRIFLUOROMETHYL)-QUINOLIN-4-AMINES [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1985, 38 (12) :1827-1835

[4] POTENTIAL ANTIMALARIALS .4. 4-[7'-BROMO( AND CHLORO)-1',5'-NAPHTHYRIDIN-4'-YLAMINO]PHENOLS AND N4-SUBSTITUTED 7-CHLORO-1,5-NAPHTHYRIDIN-4-AMINES [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1985, 38 (06) :905-911

[5]

SCOTT HV, UNPUB

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