INVESTIGATION OF THE METABOLISM OF FELODIPINE USING ONLINE LIQUID-CHROMATOGRAPHY UV DIODE-ARRAY DETECTION ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY AS A DIAGNOSTIC-TOOL

被引：11

作者：

MACRAE, PV ^{[1
]}

JONES, BC ^{[1
]}

TODD, JFJ ^{[1
]}

机构：

[1] UNIV KENT,CHEM LAB,CANTERBURY CT2 7NZ,KENT,ENGLAND

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1993年 / 7卷 / 07期

关键词：

D O I：

10.1002/rcm.1290070710

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The utility of on-line liquid chromatography coupled to UV diode array detection and atmospheric pressure chemical ionization mass spectrometry for the analysis of microsomal metabolites of felodipine has been investigated. A previously unreported metabolite of felodipine, extracted from male rat microsomes, has been detected using this technique. UV diode array detection has been used to characterize this metabolite as a dihydropyridine metabolite and tandem mass spectrometry data used to assign a structure.

引用

页码：605 / 609

页数：5

共 7 条

[1]

BAARNHIELM C, 1986, DRUG METAB DISPOS, V14, P613

[2]

BERESFORD AP, 1989, ARZNEIMITTEL-FORSCH, V39-1, P201

[3] LACIDIPINE METABOLISM IN RAT AND DOG - IDENTIFICATION AND SYNTHESIS OF MAIN METABOLITES [J].