PROTECTIVE EFFECTS OF A PROSTAGLANDIN-E1 OLIGOMER ON TAUROCHOLATE-INDUCED RAT PANCREATITIS

被引:9
作者
SAKAI, Y
HAYAKAWA, T
KONDO, T
SHIBATA, T
KITAGAWA, M
SOBAJIMA, H
NARUSE, S
OHNISHI, ST
机构
[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 2,65 TSURUMA CHO,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NATL INST PHYSIOL SCI,OKAZAKI,AICHI 444,JAPAN
[3] PHILADELPHIA BIOMED RES INST,RADNOR,PA
关键词
ACUTE PANCREATITIS; PROSTAGLANDIN-E1; OLIGOMER; PROTECTIVE EFFECT; THERAPEUTIC EFFECT; TRYPSIN-TAUROCHOLATE-INDUCED RAT; SURVIVAL RATE;
D O I
10.1111/j.1440-1746.1992.tb01491.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Effects of prostaglandin E (PGE) on acute pancreatitis have been controversial. This study shows the effects of PGE, oligomer, MR-356, on trypsin-taurocholate-induced acute pancreatitis in rats. Divided intraperitoneal doses of 0.6 mg/rat were administered, which increased 24 h survival rates when the oligomer was given both at 1 h before and after (group A) and immediately and 3 h after (group B) induction of pancreatitis. In group A MR-356 significantly improved the survival rates at 18 h (94 vs 61%, P < 0.05) and 24 h (68 vs 33%, P < 0.05) when compared with controls. MR-356 improved the survival rates dose-dependently up to 0.6 mg/rat when given by the same protocol of group A. In group B MR-356 also improved the survival rate (72 vs 39%, P < 0.05) only at 24 h, while other parameters failed to improve. The present results suggest that the PGE, oligomer may play a beneficial role in bile-induced pancreatitis, probably through its proposed effects of stabilization of lysosomal membranes, maintenance of microcirculation and inhibition of protease in the pancreas.
引用
收藏
页码:591 / 595
页数:5
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