THYROTROPIN-RELEASING-HORMONE INHIBITS GLUCOCORTICOID SECRETION OF RAT ADRENAL-CORTEX - IN-VIVO AND IN-VITRO STUDIES

被引：110

作者：

NERI, G ^{[1
]}

MALENDOWICZ, LK ^{[1
]}

ANDREIS, P ^{[1
]}

NUSSDORFER, GG ^{[1
]}

机构：

[1] UNIV PADUA, DEPT ANAT, VIA GABELLI 65, I-35121 PADUA, ITALY

来源：

ENDOCRINOLOGY | 1993年 / 133卷 / 02期

关键词：

D O I：

10.1210/en.133.2.511

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The bolus iv administration of TRH dose-dependently decreased ACTH-enhanced plasma corticosterone (B) concentration in rats, without affecting the basal one. The effects of TRH on steroid secretion of dispersed rat inner adrenocortical cells were investigated by HPLC. TRH significantly decreased both basal and ACTH-stimulated post-11-deoxycorticosterone (DOC) secretion (i.e. 18-hydroxy-DOC and B) and concomitantly raised DOC and progesterone release, so that the total postpregnenolone yield of our preparations was unaffected. TRH did not alter either basal or ACTH-stimulated pregnenolone production by isolated rat adrenocortical cells. It was concluded that TRH is an inhibitor of glucocorticoid secretion in rats, which electively impairs the late steps of B synthesis (i.e. 11- and 18-hydroxylation) without affecting the earlier steps, including the rate-limiting one of this process.

引用

页码：511 / 514

页数：4

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