PENTAMIDINE CONGENERS .1. SYNTHESIS OF CIS-BUTAMIDINE AND TRANS-BUTAMIDINE ANALOGS AS ANTI-PNEUMOCYSTIS-CARINII PNEUMONIA AGENTS

被引：14

作者：

DONKOR, IO ^{[1
]}

JONES, SK ^{[1
]}

TIDWELL, RR ^{[1
]}

机构：

[1] UNIV N CAROLINA, SCH MED, DEPT PATHOL, DIV CELLULAR BIOL & BIOL CHEM, CHAPEL HILL, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80302-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pneumonia activity in a rat model of the disease.

引用

页码：1137 / 1140

页数：4

共 13 条

[1]

FRENKEL JK, 1966, LAB INVEST, V15, P1559

[2] NEW AROMATIC DIAMIDINES WITH CENTRAL ALPHA-OXYALKANE OR ALPHA,OMEGA-DIOXYALKANE CHAINS - STRUCTURE-ACTIVITY-RELATIONSHIPS FOR INHIBITION OF TRYPSIN, PANCREATIC KALLIKREIN, AND THROMBIN AND FOR INHIBITION OF OVERALL COAGULATION PROCESS [J].

GERATZ, JD ;

CHENG, MCF ;

TIDWELL, RR .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (05) :477-481

[3] DIAMIDINO-ALPHA, OMEGO-DIPHENOXYALKANES - STRUCTURE-ACTIVITY RELATIONSHIPS FOR INHIBITION OF THROMBIN, PANCREATIC KALLIKREIN, AND TRYPSIN [J].

GERATZ, JD ;

WHITMORE, AC ;

CHENG, MCF ;

PIANTADOSI, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (09) :970-975

[4]

GORDIN FM, 1984, ANN INTERN MED, V100, P495, DOI 10.7326/0003-4819-100-4-495

[5] ASSESSMENT OF THERAPY FOR PNEUMOCYSTIS-CARINII PNEUMONIA - PCP THERAPY PROJECT GROUP [J].

HAVERKOS, HW .

AMERICAN JOURNAL OF MEDICINE, 1984, 76 (03) :501-508

[6] POLYAMINE METABOLISM IN PNEUMOCYSTIS-CARINII [J].

LIPSCHIK, GY ;

MASUR, H ;

KOVACS, JA .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (05) :1121-1127

[7]

Neilson D. G., 1975, CHEM AMIDINES IMIDAT, P385

[8] ANALOGS OF 1,5-BIS(4-AMIDINOPHENOXY)PENTANE (PENTAMIDINE) IN THE TREATMENT OF EXPERIMENTAL PNEUMOCYSTIS-CARINII PNEUMONIA [J].

TIDWELL, RR ;

JONES, SK ;

GERATZ, JD ;

OHEMENG, KA ;

CORY, M ;

HALL, JE .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (04) :1252-1257

[9]

Waalkes T P, 1976, Natl Cancer Inst Monogr, V43, P171

[10] CATIONIC ANTITRYPANOSOMAL AND OTHER ANTIMICROBIAL AGENTS IN THE THERAPY OF EXPERIMENTAL PNEUMOCYSTIS-CARINII PNEUMONIA [J].

WALZER, PD ;

KIM, CK ;

FOY, J ;

LINKE, MJ ;

CUSHION, MT .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (06) :896-905

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