THE PROTEIN IMPORT RECEPTOR OF MITOCHONDRIA

被引：141

作者：

LITHGOW, T ^{[1
]}

GLICK, BS ^{[1
]}

SCHATZ, G ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL,CHICAGO,IL 60637

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(00)88972-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.

引用

页码：98 / 101

页数：4

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