ACTIN A-INDUCED APOPTOSIS IS SUPPRESSED BY BCL-2

被引：25

作者：

KOSEKI, T

YAMATO, K

KRAJEWSKI, S

REED, JC

TSUJIMOTO, Y

NISHIHARA, T

机构：

[1] NATL INST HLTH & NUTR,DEPT ORAL SCI,SHINJUKU KU,TOKYO 162,JAPAN

[2] TOKYO MED & DENT UNIV,FAC DENT,DEPT MOLEC & CELLULAR ONCOL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

[3] LA JOLLA CANC RES FDN,CANC RES CTR,LA JOLLA,CA 92037

[4] OSAKA UNIV,SCH MED,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1995年 / 376卷 / 03期

关键词：

ACTIVIN A; APOPTOSIS; BAX; BCL-2; PROGRAMMED CELL DEATH;

D O I：

10.1016/0014-5793(95)01290-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activin A, a member of TGF beta superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX.

引用

页码：247 / 250

页数：4

共 28 条

[1] NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].