DISCRIMINATION OF TETRAHYDROAMINOACRIDINE RESPONDERS BY A SINGLE DOSE PHARMACO-EEG IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：54

作者：

ALHAINEN, K

PARTANEN, J

REINIKAINEN, K

LAULUMAA, V

SOININEN, H

AIRAKSINEN, M

RIEKKINEN, P

机构：

[1] UNIV KUOPIO, DEPT CLIN NEUROPHYSIOL, SF-70211 KUOPIO, FINLAND

[2] UNIV KUOPIO, DEPT PHARMACOL, SF-70211 KUOPIO, FINLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

基金：

芬兰科学院;

关键词：

TETRAHYDROAMINOACRIDINE; CHOLINOMIMETICS; MONOAMINE; ELECTROENCEPHALOGRAM; ALZHEIMERS DISEASE; NEUROPSYCHOLOGY;

D O I：

10.1016/0304-3940(91)90907-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the results of our study suggesting that a single dose pharmaco-EEG may predict treatment response to tetrahydroaminoacridine (THA) in Alzheimer's disease (AD). 14 AD patients and 7 age-matched neurologically healthy controls were selected for the study. AD patients had 7 weeks' THA treatment. 6 patients were regarded as responders and 8 patients as nonresponders, respectively. AD patients as well as controls had a baseline EEG recording and next day another recording 90 minutes after a peroral single dose of 50 mg THA. The relative change from the baseline in the alpha-theta ratio was the most sensitive discriminator of responders and nonresponders (P = 0.004, ANOVA).

引用

页码：113 / 116

页数：4

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