CHLORHEXIDINE HYPERSENSITIVITY OF CIPROFLOXACIN-RESISTANT VARIANTS OF PSEUDOMONAS-AERUGINOSA PAO

被引：8

作者：

BAILLIE, LWJ ^{[1
]}

POWER, EGM ^{[1
]}

PHILLIPS, I ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,ST THOMAS HOSP,DEPT MICROBIOL,LONDON SE1 7EH,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1993年 / 31卷 / 02期

关键词：

D O I：

10.1093/jac/31.2.219

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Examination of 67 ciprofloxacin-resistant dones of Pseudomonas aeruginosa PAO (ciprofloxacin MIC >0·5 mg/L) yielded four isolates that were hypersensitive to chiorhexidine (MIC 5 mg/L); none was found among 179 ciprofloxacin-sensitive colonies. Revertant studies and the introduction of a wild-type Escherichia coli DNA gyrase A gene confirmed that ciprofloxacin resistance and chlorhexidine hypersensitivity were not the result of a single mutation. Mutagenicity testing of ciprofloxacin showed no evidence for the supposition that chlorhexidine hypersensitivity was the result of ciprofloxacin-induced mutation in P. aeruginosa PAO. © 1993 The British Society for Antimicrobial Chemotherapy.

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页码：219 / 225

页数：7

相关论文

共 24 条

[1] FACTORS INFLUENCING THE ACCUMULATION OF CIPROFLOXACIN IN PSEUDOMONAS-AERUGINOSA [J].

CELESK, RA ;

ROBILLARD, NJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (11) :1921-1926

[2] ENDOGENOUS ACTIVE EFFLUX OF NORFLOXACIN IN SUSCEPTIBLE ESCHERICHIA-COLI [J].

COHEN, SP ;

HOOPER, DC ;

WOLFSON, JS ;

SOUZA, KS ;

MCMURRY, LM ;

LEVY, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (08) :1187-1191

[3] MECHANISMS OF RESISTANCE TO THE 4-QUINOLONE ANTIBACTERIAL AGENTS [J].

CRUMPLIN, GC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 :131-144

[4] ALTERATIONS IN OUTER-MEMBRANE PROTEINS OF PSEUDOMONAS-AERUGINOSA ASSOCIATED WITH SELECTIVE RESISTANCE TO QUINOLONES [J].

DAIKOS, GL ;

LOLANS, VT ;

JACKSON, GG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (05) :785-787

[5]

DALHOFF A, 1985, INFLUENCE ANTIBIOTIC, V2

[6] DETECTION OF MUTAGENIC DERIVATIVES OF CYCLOPHOSPHAMIDE AND A VARIETY OF OTHER MUTAGENS IN A MICROTITRE FLUCTUATION TEST, WITHOUT MICROSOMAL ACTIVATION [J].

GATEHOUSE, D .

MUTATION RESEARCH, 1978, 53 (03) :289-296

[7] OSMOTIC REGULATION OF PORIN EXPRESSION - A ROLE FOR DNA SUPERCOILING [J].

GRAEMECOOK, KA ;

MAY, G ;

BREMER, E ;

HIGGINS, CF .

MOLECULAR MICROBIOLOGY, 1989, 3 (09) :1287-1294

[8] USE OF A SIMPLIFIED FLUCTUATION TEST TO DETECT LOW-LEVELS OF MUTAGENS [J].

GREEN, MHL ;

MURIEL, WJ ;

BRIDGES, BA .

MUTATION RESEARCH, 1976, 38 (01) :33-41

[9]

Hubbard SA., 1984, HDB MUTAGENICITY TES, P141

[10] SOME PROPERTIES OF SUBUNITS OF DNA GYRASE FROM PSEUDOMONAS-AERUGINOSA PA01 AND ITS NALIDIXIC ACID-RESISTANT MUTANT [J].

INOUE, Y ;

SATO, K ;

FUJII, T ;

HIRAI, K ;

INOUE, M ;

IYOBE, S ;

MITSUHASHI, S .

JOURNAL OF BACTERIOLOGY, 1987, 169 (05) :2322-2325