MITOSIS AND HISTOPATHOLOGY IN RAT-LIVER DURING METHYLCLOFENAPATE-INDUCED HYPERPLASIA

被引：8

作者：

BYBEE, A ^{[1
]}

STYLES, JA ^{[1
]}

BECK, SL ^{[1
]}

BLACKBURN, D ^{[1
]}

机构：

[1] ICI PLC,CENT TOXICOL LAB,ALDERLEY PK,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

来源：

CANCER LETTERS | 1990年 / 52卷 / 02期

关键词：

binucleate; hepatocyte; histopathology; mitosis; non-genotoxic; peroxisome proliferators;

D O I：

10.1016/0304-3835(90)90250-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larger (21.3%) peak in arrested metaphases at 36 h after partial hepatectomy, but was still unexpectedly large in comparison with the S-phase response to methylclofenapate reported in a previous study [13]. Progressive hypertrophic histopathological changes were apparent during the whole course of treatment. © 1990.

引用

页码：95 / 100

页数：6

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