HIGHLY DIASTEREOSELECTIVE REDUCTION AND ADDITION OF NUCLEOPHILES TO BINAPHTHOL-PROTECTED ARYLGLYOXALS

被引：22

作者：

MAGLIOLI, P

DELUCCHI, O

DELOGU, G

VALLE, G

机构：

[1] UNIV SASSARI,DIPARTIMENTO CHIM,I-07100 SASSARI,ITALY

[2] CNR,IST APPLICAZ TECN CHIM AVANZATE PROBLEMI AGROBIOL,I-07100 SASSARI,ITALY

[3] CNR,CTR STUDI BIOPOLIMERI,I-35131 PADUA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 03期

关键词：

ALPHA-KETOACETALS; 1,1'-BINAPHTHALENE-2,2'-DIOL; DIASTEREOSELECTIVE REDUCTION; DIASTEREOSELECTIVE NUCLEOPHILE ADDITION;

D O I：

10.1016/S0957-4166(00)80276-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Arylglyoxals, protected at the aldehyde function with 1,1'-binaphthalene-2,2'-diol, are readily prepared by direct nucleophilic substitution of binaphthol-sodium salt on dibromoacetophenone and react highly diastereoselectively with lithium aluminium hydride and Grignard reagents to afford protected atrolactaldehyde and related compounds in high yield.

引用

页码：365 / 366

页数：2

共 8 条

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[8] STEREODIVERGENT SYNTHESIS OF OPTICALLY-ACTIVE TERTIARY ALCOHOLS VIA ADDITION-REACTION OF CHIRAL 2-ACYL OXAZOLIDINE WITH ORGANOMETALLICS
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