TUMOR-TARGETED BORANES .3. SYNTHESIS OF CARBAMATE-LINKED NITROIMIDAZOLYL CARBORANES DESIGNED FOR BORON NEUTRON-CAPTURE THERAPY OF CANCER

被引：22

作者：

SCOBIE, M ^{[1
]}

THREADGILL, MD ^{[1
]}

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,BATH BA2 7AY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 15期

关键词：

D O I：

10.1039/p19940002059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carboranes targetted to specific tumour tissues are important for boron neutron capture therapy of cancer (BNCT), Carbamoylation of 2-[2-[2-(2-nitroimidazol-1-yl)ethoxy]ethoxy]ethanol 5 and 1-(chloromethyl)-2-(2-nitroimidazol-1-yl)ethanol 6 with carboran-1-yl isocyanate (generated in situ by a Curtius rearrangement of carborane-1-carbonyl azide) gave the corresponding carbamate-linked nitroimidazolylcarboranes 16 and 17. A similar reaction of 4-carboranylphenyl isocyanate with 6 afforded the corresponding carbamate 24.

引用

页码：2059 / 2063

页数：5

共 32 条

[1]

BARTH RF, 1992, CANCER-AM CANCER SOC, V70, P2995

[2]

BARTH RF, 1990, CANCER RES, V50, P1061

[3]

BEAMAN AG, 1968, ANTIMICROB AGENTS CH, P520

[4]

HATANAKA H, 1986, BORON NEUTRON CAPTUR