RAS ONCOGENE PRODUCT EXPRESSION IN NORMAL AND MALIGNANT ORAL-MUCOSA

被引：11

作者：

FREER, E ^{[1
]}

SAVAGE, NW ^{[1
]}

SEYMOUR, GJ ^{[1
]}

DUNN, TL ^{[1
]}

LAVIN, MF ^{[1
]}

GARDINER, RA ^{[1
]}

机构：

[1] UNIV QUEENSLAND,DEPT SOCIAL & PREVENT DENT,IMMUNOPATHOL UNIT,ST LUCIA,QLD 4067,AUSTRALIA

来源：

AUSTRALIAN DENTAL JOURNAL | 1990年 / 35卷 / 02期

关键词：

Oncogenes; oral cancer;

D O I：

10.1111/j.1834-7819.1990.tb05880.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Proto‐oncogenes are important in both normal cellular differentiation and in carcinogenesis. The majority of transforming genes belong to the ras family and the ras gene product has been shown to be elevated in some oral carcinomas. RAP‐5 monoclonal antibody was used to determine the expression of the p21ras protein in normal and neoplastic oral mucosa in an immunohistological study. The expression of p21ras protein was generally restricted to acanthous cells with strong staining in normal oral mucosa and well‐differentiated carcinomas. In contrast, the p21ras protein was not detected in significant amounts in severely dysplastic lesions and poorly differentiated carcinomas. These results suggest that expression of p21ras is a normal feature of more fully differentiated tissues, both normal and neoplastic, and is not useful as an indicator of cell proliferation or ‘malignant potential’. 1990 Australian Dental Association

引用

页码：141 / 146

页数：6

共 16 条

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