USE OF CHARGE-SEPARATION REACTIONS FOR SEQUENCING PEPTIDES

被引：13

作者：

VEKEY, K

CANDIDO, M

TRALDI, P

机构：

[1] Merrell-Dow Research Institute, Lepetit Center, Gerenzano, Varese, 21040

[2] Cnr Area Dell Ricerca, Padova, 35100, Corso Stati Uniti

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1990年 / 4卷 / 03期

关键词：

D O I：

10.1002/rcm.1290040303

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Charge‐separation reactions of the doubly charged molecular ion of bradykinin, generated by fast‐atom bombardment, were studied. The same types of reactions occurred as in singly charged ions, but fragmentations around the middle of the peptide chain were much more abundant. This suggests that charge separation of doubly charged ions may provide more sequence information than fragmentation of singly charged species. Copyright © 1990 Heyden & Son Limited

引用

页码：74 / 76

页数：3

共 11 条

[1]

Biemann K., Martin S.A., Mass spectrometric determination of the amino acid sequence of peptides and proteins, Mass Spectrometry Reviews, 6, (1987)

[2]

Hustulrid A., Kusch P., Tate J.T., Phys. Rev., 54, (1938)

[3]

Vekey K., Brenton A.G., Beynon J.H., Comparison of [C6H6]2+ ion structures: Application of electron capture induced decomposition to the study of isomers, Organic Mass Spectrometry, 24, (1989)

[4]

Barinaga C.J., Edmonds C.G., Udseth H.R., Smith R.D., Sequence determination of multiply charged peptide molecular ions by electrospray-ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 3, (1989)

[5]

Hunt D.F., Zhu N.Z., Shabanowitz J., Rapid Commun. Mass Spectrom., 3, (1989)

[6]

Barber M., Bell D.J., Morris M., Tetler L.W., Woods M.D., Monaghan J.J., Morden W.E., Mass spectra of doubly charged ions, Organic Mass Spectrometry, 24, (1989)

[7]

Barber M., Bordoli R.S., Sedgwick R.D., Tyler A.N., Whalley E.T., Biomed. Mass Spectrom., 8, (1981)

[8]

Amster I.J., Baldwin M.A., Cheng M.T., Proctor C.J., McLafferty F.W., J. Am. Chem. Soc., 105, (1983)

[9]

Neumann G.M., Derrick P.J., Austr. J. Chem., 37, (1984)

[10]

Vekey K., Brenton A.G., Beynon J.H., J. Phys. Chem., 90, (1986)

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