IMPROVED CADAVERIC RENAL-TRANSPLANT OUTCOME IN CHILDREN

被引：104

作者：

ETTENGER, RB

ROSENTHAL, JT

MARIK, JL

MALEKZADEH, M

FORSYTHE, SB

KAMIL, ES

SALUSKY, IB

FINE, RN

机构：

[1] Department of Pediatrics, Division of Pediatric Nephrology, University of California Los Angeles School of Medicine, Los Angeles, 90024, California

[2] Department of Urology, University of California Los Angeles School of Medicine, Los Angeles, 90024, California

[3] Department of Biomathematics, University of California Los Angeles School of Medicine, Los Angeles, 90024, California

来源：

PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 01期

关键词：

RENAL TRANSPLANTATION; SEQUENTIAL IMMUNOSUPPRESSION; GRAFT SURVIVAL; IMMUNOSUPPRESSION; CYCLOSPORINE; MEDICATION NONCOMPLIANCE;

D O I：

10.1007/BF00852871

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We analyzed the results of 165 pediatric cadaver renal transplants performed at the University of California at Los Angeles to identify the factors which are linked to improved allograft survival. Both univariate life-table analysis and the Cox proportional hazard model were used. The use of a sequential immunosuppressive regimen (P < 0.001) and kidneys from donors of more than 6 years of age (P < 0.001) were found to be the factors having the most influence on primary graft survival. The sequential regimen was the only factor favorably influencing retransplants. With sequential therapy 1- and 2-year actuarial graft survival rates were 94% and 91% in primary transplants, and 82% and 70% in retransplants. Medication noncompliance exerted a large negative effect on transplant outcome. Of 70 recipients who had been on cyclosporine for at least 6 months, 50% evidenced noncompliance. Sixty-four percent of adolescents were noncompliant. Thirteen percent of the recipients lost their graft because of noncompliance. We conclude that good results can be obtained with cadaver renal transplants in children with a sequential immunosuppressive regimen and the use of kidneys from adolescent and adult donors. Noncompliance is a great barrier to long-term success in pediatric transplantation.

引用

页码：137 / 142

页数：6

共 21 条

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