PARVOVIRUS B19 SPECIFIC DNA IN BONE-MARROW FROM B19 ARTHROPATHY PATIENTS - EVIDENCE FOR B19 VIRUS PERSISTENCE

被引:105
作者
FOTO, F
SAAG, KG
SCHAROSCH, LL
HOWARD, EJ
NAIDES, SJ
机构
[1] UNIV IOWA,COLL MED,DEPT INTERNAL MED,DIV RHEUMATOL,GH E400,IOWA CITY,IA 52242
[2] VET AFFAIRS MED CTR,IOWA CITY,IA
关键词
D O I
10.1093/infdis/167.3.744
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine if B19 infection persists in patients with chronic B19 arthropathy, acute B19 infection in adults was documented by IgM serology. Bone marrow aspirates were obtained 24-42 months after acute infection in 4 patients who developed chronic joint symptoms. DNA from bone marrow aspirates was amplified by polymerase chain reaction by using B19-specific DNA sequences in the viral capsid gene and probing with B19-specific oligonucleotides in Southern analysis. B19-specific DNA sequences were detected in all 4 chronic arthropathy patients compared with 0 of 7 anti-B19 IgM-, IgG- and 0 of 6 anti-B19 IgM-, IgG+ normal bone marrow donors. Three patients with serologically proven acute B19 infection and acute but nonchronic joint symptoms had B19 DNA detected in bone marrow aspirates 2-18 months after infection. These findings suggest that B19 arthropathy is associated with persistence of either B19 virus or select B19 DNA sequences.
引用
收藏
页码:744 / 748
页数:5
相关论文
共 15 条
  • [1] ASTELL CR, 1990, HDB PARVOVIRUSES, V1, P59
  • [2] DETECTION OF HUMAN PARVOVIRUS USING A MOLECULARLY CLONED PROBE
    CLEWLEY, JP
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1985, 15 (02) : 173 - 181
  • [3] CLONING OF THE HUMAN PARVOVIRUS-B19 GENOME AND STRUCTURAL-ANALYSIS OF ITS PALINDROMIC TERMINI
    DEISS, V
    TRATSCHIN, JD
    WEITZ, M
    SIEGL, G
    [J]. VIROLOGY, 1990, 175 (01) : 247 - 254
  • [4] Kawasaki E.S., 1990, PCR PROTOCOLS GUIDE, P146
  • [5] SITE-SPECIFIC INTEGRATION BY ADENOASSOCIATED VIRUS
    KOTIN, RM
    SINISCALCO, M
    SAMULSKI, RJ
    ZHU, XD
    HUNTER, L
    LAUGHLIN, CA
    MCLAUGHLIN, S
    MUZYCZKA, N
    ROCCHI, M
    BERNS, KI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2211 - 2215
  • [6] RHEUMATOLOGIC MANIFESTATIONS OF HUMAN PARVOVIRUS-B19 INFECTION IN ADULTS - INITIAL 2-YEAR CLINICAL-EXPERIENCE
    NAIDES, SJ
    SCHAROSCH, LL
    FOTO, F
    HOWARD, EJ
    [J]. ARTHRITIS AND RHEUMATISM, 1990, 33 (09): : 1297 - 1309
  • [7] Naides SJ, 1992, CLIN VIROLOGY MANUAL, P547
  • [8] NAIDES SJ, 1992, CLIN RES, pA742
  • [9] NIADES SJ, 1991, CLIN RES, V39, pA733
  • [10] THE GENE ENCODING THE NONSTRUCTURAL PROTEIN OF B19 (HUMAN) PARVOVIRUS MAY BE LETHAL IN TRANSFECTED CELLS
    OZAWA, K
    AYUB, J
    KAJIGAYA, S
    SHIMADA, T
    YOUNG, N
    [J]. JOURNAL OF VIROLOGY, 1988, 62 (08) : 2884 - 2889